Osteosarcoma

• Age distribution: second decade, second peak incidence in late adulthood, more common in males
• Location: ends of long bones, most common around the knee and shoulder
• Presentation: pain, swelling, soft tissue mass, most common primary malignant tumor of bone
• Treatment: chemotherapy followed by resection of involved bone, the large majority of patients undergo “limb-sparing” surgery

Chondrosarcoma

• Age distribution: adulthood, rare in children
• Location: pelvis 31%, femur 21%, 6% spine
• Presentation: pain, swelling, soft tissue mass
• Treatment: mainly surgical, chemotherapy and radiation therapy limited efficacy

Ewing's sarcoma

• Age distribution: 5-30 years old
• Presentation: pain and swelling, sometimes with systemic symptoms such as fever, fatigue, malaise
• Presentation: pain, swelling, soft tissue mass, most common primary malignant tumor of bone
• Treatment: mainly surgical, chemotherapy and radiation therapy limited efficacy